Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Identifieur interne : 000405 ( Main/Exploration ); précédent : 000404; suivant : 000406Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Auteurs : Molka Feki-Tounsi [Tunisie] ; Rim Khlifi [Tunisie] ; Ibtihel Louati [Tunisie] ; Mohamed Fourati [Tunisie] ; Mohamed-Nabil Mhiri [Tunisie] ; Amel Hamza-Chaffai [Tunisie] ; Ahmed Rebai [Tunisie]Source :
- Environmental science and pollution research international [ 1614-7499 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Arylamine N-acetyltransferase (MeSH), Cytochrome P-450 CYP1A1 (génétique), Femelle (MeSH), Fumer (MeSH), Génotype (MeSH), Helicase (génétique), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Polymorphisme de nucléotide simple (MeSH), Polymorphisme de restriction (MeSH), Protéine du groupe de complémentation D de Xeroderma pigmentosum (génétique), Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X (génétique), Protéines de liaison à l'ADN (génétique), Prédisposition génétique à une maladie (MeSH), Réparation de l'ADN (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tabac (MeSH), Tumeurs de la vessie urinaire (génétique), Tunisie (MeSH), Études cas-témoins (MeSH).
- MESH :
- génétique : Cytochrome P-450 CYP1A1, Helicase, Protéine du groupe de complémentation D de Xeroderma pigmentosum, Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X, Protéines de liaison à l'ADN, Tumeurs de la vessie urinaire.
- Adulte, Adulte d'âge moyen, Arylamine N-acetyltransferase, Femelle, Fumer, Génotype, Humains, Jeune adulte, Mâle, Polymorphisme de nucléotide simple, Polymorphisme de restriction, Prédisposition génétique à une maladie, Réparation de l'ADN, Sujet âgé, Sujet âgé de 80 ans ou plus, Tabac, Tunisie, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Arylamine N-Acetyltransferase (MeSH), Case-Control Studies (MeSH), Cytochrome P-450 CYP1A1 (genetics), DNA Helicases (genetics), DNA Repair (MeSH), DNA-Binding Proteins (genetics), Female (MeSH), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Polymorphism, Restriction Fragment Length (MeSH), Polymorphism, Single Nucleotide (MeSH), Smoking (MeSH), Tobacco (MeSH), Tunisia (MeSH), Urinary Bladder Neoplasms (genetics), X-ray Repair Cross Complementing Protein 1 (genetics), Xeroderma Pigmentosum Group D Protein (genetics), Young Adult (MeSH).
- MESH :
- chemical , genetics : Cytochrome P-450 CYP1A1, DNA Helicases, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, Xeroderma Pigmentosum Group D Protein.
- chemical : Arylamine N-Acetyltransferase.
- genetics : Urinary Bladder Neoplasms.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, DNA Repair, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Smoking, Tobacco, Tunisia, Young Adult.
Abstract
Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia. The selection of the single nucleotide polymorphisms (SNPs) (rs25487, rs 13181, rs415407, rs446421, rs1058172, rs4921880, and rs1208) was performed using the dbSNP database. DNA genotyping was determined by PCR-RFLP after DNA extraction from whole blood. The risks of BC associated with every polymorphism as well as the studied environmental factors were estimated by multivariate-adjusted logistic regression using R software. In addition, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods. Results showed that tobacco smoking and chewing parameters were significantly associated with BC risk. Single-gene variant analysis showed significant associations of the TT genotype of CYP1A1 and the rare GG genotype of ERCC2 with bladder cancer susceptibility (OR = 1.34, 95% CI 1.22-1.40, P < 0.0001). According to GMDR analysis, our findings indicated a significant association between BC and gene-gene interaction among the CYP1A1, ERCC3, and XRCC1. The present results suggest a potential role of XRCC1, ERCC2, ERCC3, and CYP1A1 besides tobacco intake in susceptibility to BC.
DOI: 10.1007/s11356-017-9767-x
PubMed: 28803404
Affiliations:
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first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Louati, Ibtihel" sort="Louati, Ibtihel" uniqKey="Louati I" first="Ibtihel" last="Louati">Ibtihel Louati</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental science and pollution research international</title><idno type="eISSN">1614-7499</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Arylamine N-Acetyltransferase (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Cytochrome P-450 CYP1A1 (genetics)</term><term>DNA Helicases (genetics)</term><term>DNA Repair (MeSH)</term><term>DNA-Binding Proteins (genetics)</term><term>Female (MeSH)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Genotype (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Polymorphism, Restriction Fragment Length (MeSH)</term><term>Polymorphism, Single Nucleotide (MeSH)</term><term>Smoking (MeSH)</term><term>Tobacco (MeSH)</term><term>Tunisia (MeSH)</term><term>Urinary Bladder Neoplasms (genetics)</term><term>X-ray Repair Cross Complementing Protein 1 (genetics)</term><term>Xeroderma Pigmentosum Group D Protein (genetics)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Arylamine N-acetyltransferase (MeSH)</term><term>Cytochrome P-450 CYP1A1 (génétique)</term><term>Femelle (MeSH)</term><term>Fumer (MeSH)</term><term>Génotype (MeSH)</term><term>Helicase (génétique)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Polymorphisme de nucléotide simple (MeSH)</term><term>Polymorphisme de restriction (MeSH)</term><term>Protéine du groupe de complémentation D de Xeroderma pigmentosum (génétique)</term><term>Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X (génétique)</term><term>Protéines de liaison à l'ADN (génétique)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Réparation de l'ADN (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Tabac (MeSH)</term><term>Tumeurs de la vessie urinaire (génétique)</term><term>Tunisie (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP1A1</term><term>DNA Helicases</term><term>DNA-Binding Proteins</term><term>X-ray Repair Cross Complementing Protein 1</term><term>Xeroderma Pigmentosum Group D Protein</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Arylamine N-Acetyltransferase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytochrome P-450 CYP1A1</term><term>Helicase</term><term>Protéine du groupe de complémentation D de Xeroderma pigmentosum</term><term>Protéine-1 de complémentation croisée de la réparation des lésions induites par les rayons X</term><term>Protéines de liaison à l'ADN</term><term>Tumeurs de la vessie urinaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>DNA Repair</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Restriction Fragment Length</term><term>Polymorphism, Single Nucleotide</term><term>Smoking</term><term>Tobacco</term><term>Tunisia</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Arylamine N-acetyltransferase</term><term>Femelle</term><term>Fumer</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Polymorphisme de restriction</term><term>Prédisposition génétique à une maladie</term><term>Réparation de l'ADN</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tabac</term><term>Tunisie</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia. The selection of the single nucleotide polymorphisms (SNPs) (rs25487, rs 13181, rs415407, rs446421, rs1058172, rs4921880, and rs1208) was performed using the dbSNP database. DNA genotyping was determined by PCR-RFLP after DNA extraction from whole blood. The risks of BC associated with every polymorphism as well as the studied environmental factors were estimated by multivariate-adjusted logistic regression using R software. In addition, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods. Results showed that tobacco smoking and chewing parameters were significantly associated with BC risk. Single-gene variant analysis showed significant associations of the TT genotype of CYP1A1 and the rare GG genotype of ERCC2 with bladder cancer susceptibility (OR = 1.34, 95% CI 1.22-1.40, P < 0.0001). According to GMDR analysis, our findings indicated a significant association between BC and gene-gene interaction among the CYP1A1, ERCC3, and XRCC1. The present results suggest a potential role of XRCC1, ERCC2, ERCC3, and CYP1A1 besides tobacco intake in susceptibility to BC.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><country name="Tunisie"><noRegion><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name></noRegion><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name><name sortKey="Louati, Ibtihel" sort="Louati, Ibtihel" uniqKey="Louati I" first="Ibtihel" last="Louati">Ibtihel Louati</name><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
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